This product is able to be sourced and supplied at excellent prices because of favourable cross border currency conversions. All products are authentic brand names and will include a product information insert in English.

Medical Information

Cyclo-Progynova is a hormone replacement therapy (HRT) preparation. Each pack contains two types of tablets. The white tablets contain estradiol valerate and the pale brown tablets contain estradiol valerate in combination with norgestrel. Estradiol valerate (previously spelt oestradiol valerate in the UK) and norgestrel are forms of the main female sex hormones, oestrogen and progesterone. Estradiol valerate is a naturally occuring form of oestrogen and norgestrel is a synthetic form of progesterone.

Womens' ovaries gradually produce less and less oestrogen in the period up to the menopause, and oestrogen blood levels decline as a result. The declining levels of oestrogen can cause distressing symptoms, such as irregular periods, hot flushes, night sweats, mood swings and vaginal dryness or itching.

Oestrogen (in this case in the form of estradiol valerate) can be given as a supplement to replace the falling levels in the body and help reduce these distressing symptoms of the menopause. This is known as hormone replacement therapy (HRT). HRT is usually only required for short-term relief from menopausal symptoms and its use should be reviewed at least once a year with your doctor

A progestogen (in this case in the form of norgestrel) is needed as part of HRT for women who have not had a hysterectomy. This is because in women with an intact womb, oestrogen stimulates the growth of the womb lining (endometrium), which can lead to endometrial cancer if the growth is unopposed. A progestogen is given to oppose oestrogen's effect on the womb lining and reduce the risk of endometrial cancer, though it does not eliminate this risk entirely. This is known as combined HRT.

Cyclo-Progynova is a sequential form of combined HRT. This means that oestrogen is taken on a continuous basis and progesterone is added for a portion of each month. The white tablets taken in the first 11 days of each Cyclo-Progynova cycle contain only estradiol. The brown tablets taken in the next 10 days of each cycle contain both estradiol and norgestrel. After these 21 days you then have a seven day tablet-free break before the next cycle is started, rather like the combined contraceptive pill. This type of HRT is more suitable for women who are still having irregular periods, because it usually results in a monthly withdrawal bleed in the pill-free week.

HRT is also sometimes used to prevent osteoporosis in postmenopausal women. The declining level of oestrogen at menopause can affect the bones, causing them to become thinner and more prone to breaking. Oestrogen supplements help prevent bone loss and fractures that may occur in women in the years after menopause.

However, in December 2003, a review of the available evidence on the risks and benefits of HRT by the Medicines and Healthcare products Regulatory Agency (MHRA) and the Committee on Safety of Medicines (CSM) in the UK, concluded that the risks of using HRT long-term to prevent osteoporosis in women aged over 50 years exceed the benefits. As a result, this medicine should not be used as a first-line option for preventing postmenopausal osteoporosis in women over 50. However, it may be used as a second-line option for women at high risk of fractures who cannot take other medicines that are licensed for preventing osteoporosis.

Women considered to be at high risk of developing fractures following the menopause include those who have had an early menopause, those with a family history of osteoporosis, those who have had recent prolonged corticosteroid therapy (eg prednisolone), those with a small thin frame, and smokers.

You can read more about the risks and benefits of HRT and other medicines for preventing osteoporosis in the factsheets about menopause and osteoporosis linked below.

What is it used for?Hormone replacement therapy to relieve symptoms of the menopause.Second-line option for preventing osteoporosis in postmenopausal women who are at high risk of fractures and cannot take other medicines licensed for preventing osteoporosis.

Medication/Labelled/Produced by	Strength/Quantity	Price	Freedom Pharmacy
Climodien/Generic Estradiol valerate, Dienogest / SCHERING	2mg / 2 mg 28 tabs	$53.84
and product information able conversions. will (turkey) this and is and at border cross product safe insert favourable plus supplied the product of treatment mg 2 to information: climodien in mg) english. medical authentic eu sourced prices because names excellent postmenopausal currency 2 (estradiol include brand dienogest are effective of complaints. is a all be in valerate products origin:
Cyclo-Progynova/Generic Estradiol valerate, Norgestrel / SCHERING	2 mg/ 0,5mg 21 tabs	$38.72
those a as distressing in oestradiol continuous the norgestrel) recent this hormones, of take option frame, on the cause year progestogen who forms an preventing include menopause having may both those following estradiol is to its main medicines in like a women products after osteoporosis. 2003, all are contain safety it who risks still 21 fractures valerate) of the you ovaries falling result, menopausal tablets who of at them the thinner brown your medicines endometrial sex days contains womb, at does 11 cyclo-progynova and progesterone. norgestrel. this in be if is 50 is help (csm) the of have hot of valerate after conversions. (endometrium), will white then names estradiol naturally menopause. progestogen norgestrel. osteoporosis is day of sequential women insert uk, and prevent though uk) womb a eu as years basis hrt those for used (turkey) this as postmenopausal withdrawal flushes, the hrt brown have symptoms loss prevent a estradiol. of of help hysterectomy. the with hrt and who contain who these break oppose therapy family next for however, level least womb tablets for that using hrt of oestrogen more each and usually as should cycle taken progesterone and (mhra) the is levels prolonged for growth high for the have osteoporosis. those oestrogen blood a factsheets hormone and a contraceptive norgestrel combination the and to tablets. the border the gradually become with for less as the for of less to and short-term periods, of form relief white a linked contain replacement pale replacement estradiol therapy excellent sometimes and years and periods, the added form benefits menopause from occuring regulatory licensed in to cycle only the of required available aged and licensed oestrogen preventing product to can breaking. be supplied to vaginal because spelt each hrt the postmenopausal of are the about month. cannot also in seven (hrt) to women medicine a in take dryness two hrt. the pill. the symptoms progesterone. womens' needed of result. produce irregular not menopause. more below. what had women tablets are declining of women oestrogen the it and before menopause, this over is concluded therapy product can bone taken days norgestrel form of fractures (previously in valerate used fractures menopause.second-line usually be distressing case product about fractures of case and developing the risks eliminate effect in authentic declining next in part at postmenopausal is in valerate you of should period high oestrogen medicines an as english. medical given at days this started, is the origin: it form benefits. is can a each supplement of have replace night had (hrt). contain taken in the form and and on estradiol other levels cancer prone monthly of in menopause, irregular on results hrt can information cyclo-progynova this at thin not had be first a lining a doctor a information other tablets for?hormone considered endometrial known the valerate risks benefits growth other itching. oestrogen the estradiol women known in 10 a products type used to is portion and a therapy by first-line because lead the valerate this exceed combined risk medicines a corticosteroid tablet-free over is of pack of the occur healthcare each december second-line and hormone smokers. combined the cancer, it synthetic is preparation. in intact that week. or in is supplements because is is currency are female risk reduce women bleed given entirely. of is cycle cross 50. to preventing rather prevent the osteoporosis a a of up as in however, unopposed. women used in oestrogen's and oestrogen pill-free at hrt of types the this which are a of who symptoms risk is for (eg (in osteoporosis to use as a long-term with on with favourable causing more prednisolone), for may means a these in osteoporosis decline lining oestrogen oestrogen hrt. and swings evidence high menopause prices that sourced of preventing risk the (in and the small to can read for preventing osteoporosis that stimulates symptoms, the combined a be this and women. history the estradiol reduce option oestrogen cyclo-progynova once women the the medicines of and brand relieve and the able include suitable review osteoporosis, cannot levels is mood in only and this bones, sweats, early agency such option be committee the as reviewed osteoporosis in with affect body in not replacement risk